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SOUTH ASIAN UNIVERSITY

A University Established by SAARC Nations

SOUTH ASIAN UNIVERSITY

A University established by SAARC Nations

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Senthil Kumar Venugopal

Professor
PhD (All India Institute of Medical Sciences, New Delhi, 2000)
Molecular Medicine Laboratory Click to visit ....Laboratory

Contact Details

drsenthil(at)sau.ac.in
South Asian University ,Rajpur Rd, Maidan Garhi, New Delhi, Delhi 110068

Profile

Professional Experience:

  • Nov, 2018 – Present : Professor, South Asian University, New Delhi, India.
  • Feb, 2019 – Feb, 2022 : Dean, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi, India.
  • Jul, 2011 – Nov, 2018 : Associate Professor, South Asian University, New Delhi, India.
  • Jul,2009 – Jun, 2011 : Ramalingaswami Fellow, Institute of Liver and Biliary Sciences, New Delhi, India.
  • Apr, 2006 – Jun, 2009 : Assistant Adjunct Professor, Internal Medicine: Gastroenterology and Hepatology Division, University of California, Davis Medical Center, Sacramento, CA, USA.
  • Jul, 2004 – Mar, 2006 : Postgraduate Researcher, Internal Medicine: Transplant Research Program, University of California, Davis Medical Center, Sacramento, CA, USA.
  • Jul, 2002 – Jun, 2004 : Postgraduate Researcher, Department of Pathology, University of California, Davis Medical Center, Sacramento, CA, USA.
  • Jan, 2001 – July, 2002 : Post-doctoral Research fellow, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Jan, 1999 – Dec, 2000 : Senior Resident (Instructor), Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.

Qualifications

  • 2000: PhD in Biochemistry from All India Institute of Medical Sciences, New Delhi.
  • 1995: M.Tech. in Biotechnology from Jadavpur University, Calcutta.
  • 1993: M.Sc. in Biochemistry from Annamalai University, Tamil Nadu.
  • 1991: B.Sc. in Zoology from University of Madras, Tamil Nadu.

Recent Publications

    • Sata TN and Venugopal SK. CRISPR-Cas system: Novel experimental therapeutic and diagnostic approaches for chronic liver diseases. Int J Clin Transln Medicine 2025 (In press)

    • Mishra AK, Pant K, Gupta Parul, Hossain M, Naveen ST, Yadav AK, Zadran S, Sah AK, Nayak B, Shalimar, Venugopal SK. ALR inhibits HBV replication and autophagosome formation by ameliorating HBV-induced ROS production in hepatic cells. Virus Genes 2025 Apr;61(2):167-178.

      • Hossain MM, Mishra AK, Yadav AK, Akanksha, Ismail M, Sata TN, Sah AK, Mohit AA, Venugopal SK. MicroRNA-122 regulates inflammatory and autophagic proteins by downregulating pyruvate kinase M2 in non-alcoholic fatty liver disease. Molecular and Cellular Biochemistry 2024 Dec 4. doi: 10.1007/s11010-024-05174-y.
      • Hossain MM, Mishra AK, Yadav AK, Ismail M, Sata TN, Sah AK, Banik A, Sharma G, Venugopal SK. Free fatty acid-induced DDX3 inhibits autophagy via miR-141 upregulation in diet-induced MASLD mice model system. Annals of Hepatol. 2024 Dec 2;30(1):101758.

        • Pant K, Venugopal SK, Pisarello MJL, Gradilone SA. The Role of Gut Microbiome-Derived Short Chain Fatty Acid Butyrate in Hepatobiliary Diseases. Am J Pathol. 2023 Oct;193(10):1455-1467.
        • Yadav AK, Sata TN, Verma D, Sah AK, Mishra AK, Mrinalini, Hossain MM, Pant K, Venugopal SK. Free fatty acid-induced miR-22 inhibits gluconeogenesis via SIRT-1-mediated PGC-1α expression in nonalcoholic fatty liver disease. iliver. 2023 Mar 2 (1): 1-9.
        • Venugopal SK, Sankar P, Jialal I. Physiology, Glucagon. 2023 Mar 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
        • Mishra AK, Hossain MM, Umar M, Sata TN, Yadav AK, Sah AK, Ismail M, Nayak B, Shalimar, Venugopal SK. DDX3-mediated miR-34 expression inhibits autophagy and HBV replication in hepatic cells. J Viral Hepat. 2023 Apr;30(4):327-334.
        • Mishra AK, Hossain MM, Sata TN, Yadav AK, Zadran S, Sah AK, Nayak B, Shalimar, Venugopal SK. Hepatitis B Virus X Protein Inhibits the Expression of Barrier To Autointegration factor1 via Upregulating miR-203 Expression in Hepatic Cells. Microbiol Spectr. 2023 Feb 14;11(1):e0123522.
        • Venugopal SK, Mowery ML, Jialal I. C Peptide. 2022 May 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan.
        • Yadav AK, Sata TN, Verma D, Mishra AK, Sah AK, Hossain MM, Pant K, Venugopal SK. Free fatty acid-induced miR-181a-5p stimulates apoptosis by targeting XIAP and Bcl2 in hepatic cells. Life Sci. 2022 Jul 15;301:120625.
        • Venugopal SK, Anoruo M, Jialal I. Biochemistry, Low Density Lipoprotein. 2022 Apr 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–.
        • Vats N, Sanal MG, Venugopal SK, Taneja P, Sarin SK. Cloning of human ABCB11 gene in E. coli required the removal of an intragenic Pribnow-Schaller Box before it’s Insertion into genomic safe harbor AAVS1 site using CRISPR-Cas9. F1000Res. 2020 Dec 23;9:1498. 
        • Vats N, Dubey RC, Sanal MG, Taneja P, Venugopal SK. Glibenclamide, ATP and metformin increases the expression of human bile salt export pump ABCB11. F1000Res. 2020 Dec 22;9:1497. 
        • Gupta P, Venugopal SK. Augmenter of liver regeneration: A key protein in liver regeneration and pathophysiology. Hepatol Res. 2018 Apr 6. TGF-β induces liver fibrosis via miRNA-181a-mediated down regulation of augmenter of liver regeneration in hepatic stellate cells. Gupta P, Sata TN, Yadav AK, Mishra A, Vats N, Hossain MM, Sanal MG, Venugopal SK. PLoS One. 2019 Jun 5;14(6):e0214534. 
        •  Butyrate inhibits HBV replication and HBV-induced hepatoma cell proliferation via modulating SIRT-1/Ac-p53 regulatory axis. Pant K, Mishra AK, Pradhan SM, Nayak B, Das P, Shalimar D, Saraya A, Venugopal SK. Mol Carcinog. 2019 Apr;58(4):524-532.
        • Singh AK, Rooge SB, Varshney A, Vasudevan M, Bhardwaj A, Venugopal SK, Trehanpati N, Kumar M, Geffers R, Kumar V, Sarin SK. Global micro RNA expression profiling in the liver biopsies of Hepatitis B Virus infected patients suggests specific miRNA signatures for viral persistence and hepatocellular injury. Hepatology. 2018; 67: 1695-1709.
        • Pant K, Misra AK, Venugopal SK. MicroRNAs in the progression of hepatocellular carcinoma. In MicroRNA: Prospectives in Health and Diseases. Ed. Paul J. Publisher: CRC Press. Taylor & Francis Group. 2018; 141-172.
        • Dhole B, Gupta S, Venugopal SK, Kumar A. Triiodothyronine stimulates VEGF expression and secretion via steroids and HIF-1a in murine Leydig cells. Systems Biol Reprod Med. 2018; 64:191-201.
        • Pant K, Yadav AK, Gupta P, Islam R, Jain A, Saraya AN, Venugopal SK. Butyrate induces ROS-mediated apoptosis via modulation of miRNA-22/SIRT-1 regulatory axis in Hepatoma cells. Redox Biol. 2017; 12:340-349.
        • Pant K, Saraya AN, Venugopal SK. Oxidative stress plays a key role in butyrate-mediated autophagy via Akt/mTOR pathway in hepatoma cells. Chem Biol. Interactions. 2017;  273:99-106.
        • Pant K and Venugopal SK. Circulating microRNAs: Possible role as non-invasive diagnostic biomarkers in Liver diseases. Clin Res in Hepatol and Gastro. 2017; 41: 370-377.
        • Pant K, Yadav AK, Gupta P, Rathore AS, Naik B, Venugopal SK. Humic acid inhibits HBV-induced autophagosome formation and induces apoptosis in HBV-transfected Hep G2 cells. Scientific Reports. 2016;6:34496.
        • Pant K, Gupta P, Damania P, Yadav AK, Gupta A, Ashraf A, Venugopal SK. Mineral pitch induces apoptosis and inhibits proliferation via modulating reactive oxygen species in hepatic cancer cells. BMC Complement Alternate Med. 2016;16(1):148.
        • Kumar S, Gupta P, Khanal S, Shahi A, Kumar P, Sarin SK, Venugopal SK. Hepatitis B Virus X protein induces autophagosome formation by inhibiting microRNA-30a via targetting beclin-1 in hepatic cells. FEBS J. 2015; Mar 282(6):1152-63.
        • Damania P, Sen B, Dar SB, Kumar S, Kumari A, Gupta E, Sarin SK, Venugopal SK. Hepatitis B virus induces cell proliferation via HBx-induced microRNA-21 in hepatocellular carcinoma by targeting programmed cell death protein4 (PDCD4) and phosphatase and tensin homologue (PTEN). PLOS one. 2014 Mar 14;9(3):e91745.

        Awards & Honours

        • Ramalingaswami fellowship, Department of Biotechnology, Govt. of India. 2009.
        • 10-50K Innovative Development Award Program, University of California Davis, 07/07-06-09.
        • Travel Award for Academic Skills Workshop from American Gastroenterological Association, 2008.
        • Travel Award for International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis, 2006.
        • Harrison Endowed Chair in Diabetes Research Grants Award from Treadwell Foundation, 1/03-12/03.
        • Travel Award for Oxford Workshop (UK) by European Association for Diabetes Study (EASD)/ Juvenile Diabetes Research Foundation (JDRF), 2001.
        • Senior Research Fellowship Award from Indian Council of Medical Research, Government of India, India, 11/96-12/98.
        • Fellowship Award from the Department of Biotechnology, Govt. of India, India 09/93-05/95.

        Last Updated : 16 Apr 2025