| Translational Neuroscience & Clinical Biomarkers | Exosome biology | Cardiovascular biomarkers| Multi-omics biomarker research | Computational biology & Bioinformatics |
Research Officer & Teaching Assistant, SAU, Delhi (2026) | Project Investigator Scientist, IHBAS, Delhi (2022-2026) | PhD, Postdoctoral fellow & Project Investigator Scientist, AIIMS, Delhi (2011-22) | Project Assistant, CSIR-IGIB, Delhi (2010-11) |
Neurodegenerative Diseases: Investigating pathogenic pathways in Parkinson’s and Alzheimer’s diseases, specifically the prion-like seeding mechanisms of alpha-synuclein and amyloid beta.
Exosome Biology & Multi-Omics: Developing innovative workflows for small extracellular vesicle isolation from clinical samples to identify early diagnostic and non-invasive biomarkers for cardiovascular and neurological conditions
Characterization of Intrinsically Disordered Proteins (IDPs)
Proteomics, Multi-Omics & Method Development
• Sharma P*, Dhamija RK. A streamlined method for isolating and characterizing small extracellular vesicles from human biofluids. BMC Methods. 2025 | First and corresponding author |
• Sharma P*, Dhamija RK. A comprehensive method for isolating proteins from serum, CSF, and neurons for LC-MS/MS proteomics. Biochemistry and Biophysics Reports. 2025 | First and corresponding author |
Cardiovascular Diseases (Atherosclerosis / CAD)
• Sharma P* et al. Salivary small extracellular vesicles reveal protein signatures in young patients with coronary artery disease. BMC Clinical Proteomics. 2025 | First and corresponding author |
• Sharma P* et al. Proteomic profiling of urinary exosomes for early non-invasive biomarkers in CAD. Journal of Proteomics. 2023 | First and corresponding author | Work featured in Hindustan Times on World Heart Day, 2025, for its impact on clinical diagnostics |
• Sharma P* et al. Structural analysis of exosomes in atherosclerotic cardiovascular disease using electron microscopy. Microscopy and Microanalysis. 2023 | First and corresponding author |
Neurodegenerative Disorders (Parkinson’s, Alzheimer’s, Dementia)
• Sharma P*, Dhamija RK. The quest for Parkinson’s disease biomarkers: traditional and emerging multi-omics approaches. Molecular Biology Reports. 2025. | First and corresponding author |
• Sharma P*, Srinivasan A, Dhamija R. Hippocampal protein interaction with Alzheimer's amyloid beta peptide: 14–3-3 zeta and Tubulin beta promote tau phosphorylation. Journal of the Neurological Sciences. 2023. | First and corresponding author |
• Sharma P, et al. Can apolipoproteins and complement factors be biomarkers of Alzheimer's disease? Current Alzheimer Research. 2012. | Co-First author |
Structural Biology / Bioinformatics
• Sharma P* et al. Comprehensive amino acid composition analysis of seed storage proteins and intrinsically disordered peptides. J Biomol Struct Dyn. 2024. | First and corresponding author |
• Sharma P* et al. Multifaceted nature of mollusk shell proteins and biomineralization. J Biomol Struct Dyn. 2024 | First and corresponding author |
Research Integrity & Ethics
• Sharma P* et al. Systematic review of retractions in biomedical research publications. Humanities and Social Sciences Communications. 2023 | First and corresponding author | (featured in News of Dainik Bhaskar, 2023)
| Secured 1st Young Investigator in Clinical Research at the ISAR Annual Conference (2022) | | Secured 1st Poster presentation award at 9th International Conference on Proteomics (Paris, 2017)| Secured 3rd Oral presentation award at the ISAR Annual Conference (2024) | Recipient of the ICMR Centenary Post-Doctoral Fellowship and Women Scientist Fellowships from both DST and DHR | International Travel Awards: Recognized by DST-SERB (ANRF), ICMR, and CSIR for presentations in Lyon, France (2024); Lisbon, Portugal (2024); and Seoul, South Korea (2025); Awarded the GP Talwar Award (Paris, 2017 & Luxembourg, 2023) | Secured Rank 1 in the PhD entrance examination at AIIMS, Delhi (July 2011) & individual ICMR Research Fellowship during the PhD |
Professional Memberships & Editorial roles
| Delhi Neurological Association | European Atherosclerosis Society | American Heart Association and Stroke Society | The Alzheimer's Association (ISTAART) | International Parkinson and Movement Disorder Society (MDS) | Indian Society of Atherosclerosis Research (ISAR), IAS (International Atherosclerosis Society) & Delhi Chapter | Electron Microscope Society of India (EMSI) | Editorial responsibilities: J of CNS Diseases, Frontiers in Genomics, Frontiers in Medicine |
Selected Grants and Funded Projects
Principal Investigator (PI): "Streamlining the utility of αlpha-Synuclein RT-QuIC method as a novel diagnostic tool in Parkinson’s Disease" (DHR funded- Ongoing)
Principal Investigator (PI): "Unravelling early biomarkers from biofluid exosomes via iTRAQ-based quantitative proteomics in cardiovascular disease" (DHR funded- Completed)