Associate Professor (SG), South Asian University, New Delhi (2023-cont.)
Associate Professor, South Asian University, New Delhi (2019-2023)
Assistant Professor (SG), South Asian University, New Delhi (2016-2019)
Assistant Professor, South Asian University, New Delhi (2011-2016)
Research Associate, Institute of Genomics and Integrative Biology, Delhi (2010-2011)
Postdoctoral Fellow, Weizmann Institute of Sciences, Israel (2006-2009)
Senior Research Fellow, Banaras Hindu University, Varanasi, India (2005-2006)
Qualifications
PhD from the Department of Zoology, Banaras Hindu University, in 2005
MSc in Zoology (Molecular, Applied and Clinical Genetics) from the Department of Zoology, Banaras Hindu University, in 2001
BSc with Zoology (Hons.), Botany and Chemistry from Banaras Hindu University, in 1999
Research Interests
Designing and Production of Monoclonal Antibodies (VH/VL Nanobody, scFv & IgG), and Multi-epitope Peptide Vaccines against the Dengue Virus
Redesigning Human Lactonases (PONs and
SMP30) for Enhanced Organophosphate Degradation and Anti-biofilm Property
Rational Designing of Bacterial and Human Chitinases for Improved Anti-Cancer Property
Antibody Engineering for Cancer Immunotherapy
Recent Publications
Shrivastava A, Goel M, Khalid MF,
Yadav P, Maharjan S, Gupta RD*. Elucidating the functional significance
of catalytic and chitin-binding domains for the anti-cancer property of a
bacterial endochitinase. Journal of Genetic Engineering and Biotechnology,
Volume 23, Issue 4, 2025, 100596, ISSN 1687-157X, https://doi.org/10.1016/j.jgeb.2025.100596.
Goel
M, Yadav P, Parween F, Mukherjee S, Gupta RD*. Anti-biofilm efficiency
and substrate specificity of recombinantly produced human paraoxonases. Enzyme
Microb Technol. 2025 Oct 8;192:110760. doi: 10.1016/j.enzmictec.2025.110760.
PMID: 41076986.
Yadav P, Goel M, and Gupta RD*.
Rational designing of human senescence marker protein 30 for enhanced
hydrolysis of V-type nerve agent analog. Biochemical Engineering Journal,
Volume 223, November 2025, 109862 DOI:
10.1016/j.bej.2025.109862
Shrivastava A, Goel M,
Khalid MF, Sharma G, Khandelwal A, Sharma D, & Gupta RD*. Evaluation of the
Recombinant Bacterial Chitinases as Anti-proliferative and Anti-migratory
Agents for the Human Breast Cancer Cell Line, MCF-7. Applied Biochemistry
and Biotechnology. February 23, 2024. doi:10.1007/s12010-024-04888-5, PMID: 38393581
Yadav P, Goel M,
Gupta RD*. Anti-biofilm Potential of
Human Senescence Marker Protein 30 against Mycobacterium smegmatis. World
Journal of Microbiology and Biotechnology, December 2023, 40-45 (1-13).
doi: 10.1007/s11274-023-03843-6, PMID: 38114754
Sarker
A, Dhama N, Gupta RD*. Dengue virus neutralizing antibody: a review of targets,
cross-reactivity, and antibody-dependent enhancement. Frontiers in Immunology,
2023 Jun 2;14:1200195. doi: 10.3389/fimmu.2023.1200195. PMID: 37334355.
Chaturvedi M, Joy S, Gupta
RD, Pandey S, Sharma S. Endocrine Disrupting Chemicals (EDCs): Chemical
fate, Distribution, Analytical methods and Promising Remediation Strategies - A
Critical Review. Environmental Technology Reviews. 2023, 12(1): 286-315,
doi: 10.1080/21622515.2023.2205026
Sarker A,
Rathore AS, Khalid MF, Gupta RD*.
Structure-guided affinity maturation of a single-chain variable fragment
antibody against the Fu-bc epitope of the dengue virus envelope protein. Journal
of Biological Chemistry. 2022 Feb 23:101772. doi:
10.1016/j.jbc.2022.101772. PMID:
35218775
Parween F, Yadav P, Singh K, Gupta RD*. Production of highly soluble native human paraoxonase 2 with potential anti-biofilm property. Preparatory Biochemistry and Biotechnology. 2022 Jul 20:1-10. doi: 10.1080/10826068.2022.2101000. 1.PMID: 35856452.
Parween F, Sarker A,
Gupta RD*. Chlorpyrifos and parathion regulate oxidative stress
differentially through the expression of paraoxonase 2 in human neuroblastoma
cell. NeuroToxicology. 2022 Sep 1;93:60-70. doi: 10.1016/j.neuro.2022.08.016. PMID: 36058312.
Parween F, Gupta RD*. Insights into the role of paraoxonase 2 in human
pathophysiology. Journal of Biosciences. 2021; 46:4. doi: 10.1007/s12038-021-00234-7. PMID: 34987135.
Parween F,
Hossain MS, Singh KP, Gupta RD*. Association between human paraoxonase 2 protein and
efficacy of acetylcholinesterase inhibiting drugs used against Alzheimer's
disease. PLoS One. 2021
Oct 29; 16(10): e0258879. doi: 10.1371/journal.pone.0258879. PMID: 34714861
Deswal N, Shrivastava A, Hossain MS, Gahlyan P, Bawa R, Gupta RD and Kumar R. Design, Synthesis, Evaluation
and Molecular Docking Studies of Novel Triazole Linked
1,4‐Dihydropyridine‐isatin Scaffolds as Potent Anticancer Agents. January 2021,
ChemistrySelect6(4):717-725,
doi: 10.1002/slct.202003948
Hossain MS, Dutta RK, Muralidhar K, Gupta RD*. Decreased ascorbic acid
biosynthesis in response to PMSG in the pre-pubertal female rat ovary. Research
in Veterinary Science, 2020 Apr 4;131:15-20. doi: 10.1016/j.rvsc.2020.03.028, PMID: 32278959.
Rathore AS, Sarker A, Gupta RD*. Production and
immunogenicity of Fubc subunit protein redesigned from DENV envelope protein. Applied Microbiology and Biotechnology,
2020
May;104(10):4333-4344. doi: 10.1007/s00253-020-10541-y, PMCID: PMC7223326
Agarwal D,
Singh S, Gupta RD, Awasthi SK. In
vitro synergistic interaction of potent 4-aminoquinolines in combination
with dihydroartemisinin against chloroquine-resistant Plasmodium falciparum. Acta
Tropica, 2019 Jul 24:105109. doi:
10.1016/j.actatropica.2019.105109, PMID: 31351071.
Dutta RK, Parween F, Hossain MS, Dhama N, Pandey P, Gupta RD*. Comparative analysis of the metal-dependent structural and
functional properties of Mouse and Human SMP30. PLoS One. 2019,
Jun 20;14(6):e0218629. doi:
10.1371/journal.pone.0218629. PMID: 31220150.
Sarker A,
Rathore AS, Gupta RD*.
Evaluation of scFv protein recovery from E.
coli by in vitro refolding and
mild solubilization process. Microbial
Cell Factories. 2019 Jan
14;18(1):5. doi: 10.1186/s12934-019-1053-9. PMID: 30642336.
Rathore AS,
Sarker A, Gupta RD*. Designing
antibody against highly conserved region of dengue envelope protein by in
silico screening of scFv mutant library. PLoS One. 2019
Jan 10; 14(1):e0209576. doi:
10.1371/journal.pone.0209576. PMID: 30629625.
Rathore AS, Sarker A, Gupta RD*. Recent developments toward
antibody engineering and affinity maturation. Protein and Peptide Letters, 2018, 25 (10): 886-896.PMID: 30255742.
Rathore AS, Gupta
RD* (2015) Chitinases from Bacteria to
Human: Properties, Applications, and Future Perspectives. Enzyme Research, 2015(2):1-8. doi:
10.1155/2015/791907
Gupta RD, Goldsmith M, Ashani Y,
Simo Y, Mullokandov G, Bar H, Ben-David M, Leader H, Margalit R, Silman I,
Sussman JL and Tawfik DS (2011) Directed evolution of hydrolases for prevention
of G-type nerve agent intoxication. Nature
Chemical Biology 02/2011; 7(2):120-5. doi:
10.1038/nchembio.510
Gupta RD
and Tawfik DS. Directed enzyme evolution via small and effective neutral drift
libraries. Nature Methods . 11/2008; 5(11):939-42.doi: 10.1038/nmeth.1262
Awards & Honours
Fellowship from the DST’s FAST track scheme for young scientists in Life Sciences (2012)
Fellowship from the DST’s FAST track scheme for young scientists in Chemical Sciences (2011)
CSIR-Research Associate Fellowship (2010)
Post-Doctoral Fellowship from the Weizmann Institute of Sciences (2006)
CSIR-Senior Research Fellowship (2004)
CSIR –Junior Research Fellowship (2002)
Patents:
Rinkoo D. Gupta, Animesh Sarker, Abhishek S Rathore “An Antibody or An Antigen Binding Fragment Thereof Against Dengue” Indian patent Application No.: 202111017607 filed on 15th April 2021, and published on 24th February, 2023.
Dan S Tawfik, Rinkoo D Gupta, Moshe Goldsmith, Yaacov Ashani, Israel silman, Ben-David, Joel Sussman (2011) “Isolated PON1 Polypeptides, Polynucleotides Encoding Same and Uses Thereof in Treating or Preventing Organophosphate Exposure Associated Damage”. Ref. No: WO/ 2011/033506 /A2, Year: 03/2011.
